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Products and Services

The Centre for the Technologies of Gene and Cell Therapy (CTGCT) serves as a facilitator for translational medicine, connecting local, regional and continental biomedical and biopharmaceutical entities. The centre’s ultimate mission is to enable the development of proprietary cell and gene therapies.

If you are interested in one of our products and services or require a bespoke solution, do not hesitate to contact us. Our team would be happy to discuss your requirements and propose the best solution based on the expertise of our scientist.

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1. Translational Clinical Development

Our team is combining state-of-the-art experimental approaches with strong development know how, towards new solutions in GCT market segments along strictly defined regulatory pathways.

We focus on technology platforms for treating conditions that are treated as niche by the mainstream pharmaceutical industry.

Our approaches are supported with rock-solid QC and QA solutions, navigated with a creative zeal and a strong desire to enable new therapies to reach the patients.

  • In vitro.
  • In vivo.
  • Personalized in vitro models based on patient’s iPSCs
  • Models for CAR-T cell therapy against solid and haematological cancers.
  • Preclinical testing in mice (non-GMP, GLP-compliant), organoids and fibroblasts.

  • Efficacy studies.
  • Toxicity testing.
  • Biodistribution testing.
  • Pharmacokinetics.
  • Pharmacodynamics.

  • Experiment design.
  • Cloning and primer development.
  • Protein design, synthesis and purification techniques
  • Protein characterisation.
  • RNA therapies design, synthesis and testing.
  • Lenti virus development.
  • AAV development.
  • Lipid nanoparticle (LNP) formulation.
  • Advanced particle size and molecular analysis.
  • In vitro and in vivo cell phenotyping eg. lymph nodes or spleen).
  • Custom research and data analysis for biomedical studies.

  • Research-grade and GMP-like grade production of Lentiviruses.
  • Research-grade production of AAVs
  • Custom mouse models using CRISPR-Cas.
  • Delivery systems – viral and non-viral.
  • Production process development.

  • Host strain: Identity and purity, presence of plasmid and extraneous agents assays.
  • pDNA; identification, genetic integrity, DNA (concentration, purity, topology),
    host residuals (DNA, RNA, proteins).
  • Production cells: identity and purity, extraneous agents assays, tumorigenicity.
  • Viral vectors: potency (functional and physical titer), purity (host cell DNA and proteins, pDNA, endonuclease, DNA size distribution), safety (sterility, endotoxins, mycoplasma, adventitious agents, recombinant competent viruses) and identity (specific viral sequences and proteins).
  • Final lot assays: particle analysis (size, contamination), osmolality, pH, extractable volume, expression of genetic insert, biological activity

2. Business Services

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  • Advisory on GMP, GLP, GSO, BSL2 and ATMP compliance for cell & gene therapy.
  • Consultation on early regulatory approval pathways for rare disease therapies.
  • Support for orphan drug designation and fast-track approvals in the EU.

  • Assistance in securing EU funding (Horizon, IHI, EIC, ERC, national grants).
  • Investor networking for biotech startups in gene & cell therapy.
  • Market Access support with payers for affordable therapy commercialization.

  • Specialized training in viral vector production, CRISPR, synthetic biology, and LNP production.
  • Hands-on GMP and GLP workshops for biotech professionals.
  • AI-driven bioinformatics courses and AI-Driven protein design.

  • Organizing translational medicine conferences, thematic roundtables and workshops.
  • Facilitating academic-industry-hospital partnerships for biopharmaceutical innovation.
  • Facilitating patient engagement in advancing development of therapies for rare diseases.
  • Public engagement and awareness campaigns for gene and cell therapies.

3. Labs and Tools

  • Cell lab facility for preclinical studies on IPSC / organoids under GLP.
  • Bioprocessing tools such as bioreactors.

  • Instruments for anaesthesia, blood sample collection, and blood pressure acquisition (Harvard Apparatus)
  • Respirators for laboratory personnel (biosafety level II) (DateSand)
  • Stereomicroscope (NIKON SMZ 1500) ),
  • Surgical microscope OPMI (Zeiss),
  • Fluorescence microscope with two micro-injectors (Leica);
  • System for ventilation and air recovery with cages (Rosenberg, Techniplast)
  • Station for bedding disposal DS36L and changing station CS5 with atomizer (Techniplast);
  • Biosafety II laminar with an atomizer (BS-48) (Tecniplast)
  • Abaxis Vetscan VS2 for biochemistry profile analysis
  • Abaxis Vetscan HMM5 for five-part differential hematology analysis
  • Microtome RR245 (Leica)
  • IVIS Spectrum in the vivo imaging system (Perkin Elmer)

  • High throughput confocal microscope CX7 (Thermo) for kinetics measurement
  • Confocal laser microscope TCS SP5 (Leica);
  • Confocal laser microscope TCS SP8 SMD for single-cell analysis (FCS, FCCS, FLCS, FRET and FLIM) with white light laser (Leica)
  • Microplate reader with injectors (luminescence) (Berthold Detection Technologies);
  • Microplate reader with injectors (absorbance, fluorescence) Synergy (Bio-Tek);
  • Fluorimeter LS55 (Perkin Elmer);
  • Flow cytometer and cell sorter (Attune), S3e (Bio-Rad);
  • Spectral flow cytometer Aurora (Cytek);
  • Cytek Aurora and Attune NxT cytometers for immunophenotyping.
  • Nuclear Magnetic Resonance lab.
  • Latest AFM.
  • Optical tweezers with TIRF (DNA/protein-PAINT).
  • IVIS Spectrum in the vivo imaging system (Perkin Elmer) (animal)

  • Malvern Zeta sizer for particle size measurement.
  • Documentation system G:box (Syngen)
  • Analytical systems for protein characterization (e.g., chromatography and mass spectrometry).
  • MS analysis.
  • CD spectrometer with titrator and adjustable temperature (Applied Photophysics);
  • HPLC systems (Shimadzu, Agilent, Pharmacia);
  • High-capacity centrifuge (Beckmann)
  • Protein detection systems: Western Blot, iBindFlex, Elisa, and Semidry WB modules.

  • Documentation system GelDock Go imaging system
  • Electroporator (Bio-Rad)
  • Quantitative PCR in real-time LC480 (Roche)
  • DNA analysis tools: QIAxcel Advanced, PCR machines, nanodrop systems.
  • Spectrophotometers and mass spectrometers.

  • Research ultrasound platform VANTAGE 64LE (Verasonics) with 128 transmit and 64 receive channels
  • Transducers L22-14vX Linear Array Transducer (Verasonics), 0.5, 1, and 2.3 MHz transducers (Olympus), 1 and 3 MHz transducers (Precision Acoustics)

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Contact us

In case you would want to receive more information about our products and services do not hesitate write us an email.

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