ArticlesPacientsResearchersATMPsGMPLaboratoryManufacturing ProcessPre ClinicalUMCUtrechtRodrigo Ortiz 9 December 2025 Bridging the Gap: The Role of GMP Simulation in ATMP Translation In recent decades, the medical toolbox has expanded dramatically. While traditional medicine relied on synthetic drugs (small molecules interacting with specific pathways) and later biologicals like antibodies, we have now entered the era of ... More
ArticlesCliniciansPacientsResearchersGen TherapyResearchCTGCTNICRodrigo Ortiz 25 September 2025 From Film Editing to RNA Editing: How RNA Trans-splicing Could Treat CTNNB1 Syndrome Imagine you're in a movie editing studio, trying to fix a film with some corrupted scenes. The film is vital, as it plays a crucial role in the development and function of an entire ... More
ArticlesCliniciansPacientsClinic studyRegulationCTGCTNICGregor Cuzak 16 July 2025 CTIS public portal – a great tool for finding and exploring clinical trials in Europe The Clinical Trials Information System (CTIS) public portal is a new European tool that allows anyone to access information about clinical trials taking place in the European Union (EU) and European Economic Area (EEA). ... More
ArticlesCliniciansPacientsResearchersGen TherapyResearchRodrigo Ortiz 5 June 2025 Unraveling the Mysteries of NLRP3: A Key Player in Inflammation In the complex world of cellular biology, proteins play a crucial role in maintaining our body's health and responding to threats. One such protein, NLRP3, is known for its ability to assemble the inflammasome ... More
ArticlesCliniciansPacientsResearchersCell therapyGen TherapyLaboratoryResearchCTGCTNICRodrigo Ortiz 3 June 2025 Harnessing Synthetic Biology for Innovative Medical Treatments In the world of synthetic biology, scientists are pushing the boundaries of what's possible by designing proteins that can be controlled in specific ways. This review written by Tjaša Plaper, Urška Knez Štibler and ... More
ArticlesCliniciansPacientsResearchersCell therapyResearchCTGCTNICRodrigo Ortiz 28 May 2025 How Ultrasound Can Control Cells, the Future of Medicine? Members of our team have already published work on sonogenetics (check our article breaking down that research here). We think this could have interesting applications in the future, since it overcomes the issue of ... More
ArticlesEventsCliniciansPacientsResearchersGen TherapyRaziskaveCTGCTNICRodrigo Ortiz 8 April 2025 Event Date: 21 March 2025 do: 21 March 2025 • CTGCT’s Role in the GeneH Project: Accelerating Gene Therapy Innovations We are thrilled to announce our participation in the GeneH consortium, an ambitious project led by the University of Coimbra, and their GeneT project, colead by the Kemijski Inštitut with the CTGCT project, aimed ... More
ArticlesCliniciansResearchersATMPsCell therapyGen TherapyManufacturing ProcessRegulationCTGCTUMCUtrechtRodrigo Ortiz 5 March 2025 Navigating Viral Vector Production for Gene Therapy This week we had the opportunity to listen to Ganesh Ramesh, a PhD candidate at the Viral Vector Production Center for Translation Immunology of UMC Utrecht, under the supervision of Dr. Zsolt Sebestyen. Here ... More
ArticlesPacientsATMPsCell therapyGen TherapyBusiness ModelEconomicsPre ClinicalResearchCTGCTNICRodrigo Ortiz 28 February 2025 How Patient Advocacy is Driving Breakthroughs to Treat CTNNB1 Syndrome Imagine a world where a child’s genetic disorder, once considered untreatable, is finally on a path toward real solutions. For families affected by the CTNNB1 syndrome, that future is becoming a reality thanks to ... More
ArticlesCliniciansPacientsResearchersATMPsCell therapyResearchCTGCTNICRodrigo Ortiz 25 February 2025 Controlling Cells With Chemically Switchable Antibodies: A New Opportunity For Precision Therapy Imagine being able to turn a cell’s behavior ON or OFF, just like flipping a light switch. That’s exactly what scientists have achieved with the innovative technology presented in this paper published in the ... More
ArticlesPacientsCTGCTGregor Cuzak 18 February 2025 Hugs for rare The 28th of February is approaching which is the Day of Rare diseases. Hugs are being collected in 7 countries to raise awareness of the importance of everyone working together to defeat rare diseases. More
ArticlesPacientsResearchCTGCT 11 February 2025 Women at CTGCT: Voices from the Lab Today we we celebrate the International Day of Women and Girls in Science, we take a moment to spotlight the women working at the Centre for the Technologies of Gene and Cell Therapy (CTGCT) More
